If you think of your genome as a book, the repeatome would be the pages of footnotes at the end. Long considered “junk DNA,” these stretches of genetic material have remained largely unexplored, until now. ROME Therapeutics is a biotechnology startup that aims to change that. By unlocking the potential of the repeatome, ROME is developing novel therapies for cancer and autoimmune diseases, bringing hope to millions of patients worldwide.
A New Frontier in Biology
For years, researchers have focused on protein-coding genes as the key to understanding human biology and developing drugs. However, recent studies have revealed that only about 2% of the human genome actually codes for proteins. The rest, including the repeatome, was thought to be non-functional “junk DNA” with no biological significance.
But that view is changing. Advances in genomics and computational biology have shown that the repeatome plays a critical role in regulating gene expression and cellular function. In fact, repeat elements make up almost half of the human genome, making them a vast, untapped resource for drug discovery.
Harnessing the Power of Repeatome
ROME Therapeutics is at the forefront of this emerging field, developing innovative therapies that target the repeatome to treat cancer and autoimmune diseases. By identifying and characterizing repeat elements involved in disease, ROME aims to design small molecules and other modalities that selectively modulate the expression of disease-associated genes.
To achieve this ambitious goal, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology, and machine learning. With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology.
A Bright Future Ahead
With its groundbreaking approach and strong team, ROME Therapeutics is poised to make a significant impact on the biotech industry. Its mission to unlock the potential of the repeatome and develop effective therapies for cancer and autoimmune diseases has the potential to transform the lives of millions of patients worldwide.
As ROME Therapeutics continues to push the boundaries of science and innovation, we can look forward to a future where new treatments are available for some of the most challenging diseases of our time.